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Long working hours as a risk factor for atrial fibrillation
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Long working hours as a risk factor for atrial fibrillation

a multi-cohort study


Aims: Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (≥55 per week) and those working standard 35-40 h/week.

Methods and results: In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991-2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI = 1.13-1.80, P = 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I2 = 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N = 2006, hazard ratio = 1.36, 95% CI = 1.05-1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association.

Conclusion: Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.

Kivimäki, M., Nyberg, S. T., Batty, G. D., Kawachi, I., Jokela, M., Alfredsson, L., ... IPD-Work consortium (2017). Long working hours as a risk factor for atrial fibrillation: a multi-cohort study. European Heart Journal, 38(34), 2621-2628. DOI: 10.1093/eurheartj/ehx324
Author(s) Mika Kivimäki
Solja T Nyberg
G David Batty
Ichiro Kawachi
Markus Jokela
Lars Alfredsson
Jakob B Bjorner
Marianne Borritz
Hermann Burr
Nico Dragano
Eleonor I Fransson
Katriina Heikkilä
Anders Knutsson
Markku Koskenvuo
Meena Kumari
Ida E H Madsen
Martin L Nielsen
Maria Nordin
Tuula Oksanen
Jan H Pejtersen, SFI
Jaana Pentti
Reiner Rugulies
Paula Salo
Martin J Shipley
Sakari Suominen
Töres Theorell
Jussi Vahtera
Peter Westerholm
Hugo Westerlund
Andrew Steptoe
Archana Singh-Manoux
Mark Hamer
Jane E Ferrie
Marianna Virtanen
Adam G Tabak
Publication date 07.09.2017
Published in European Heart Journal
Language English
Nr. of pages 8
Department Employment, Education and Social Inclusion
keywords Societal and employment-related aspects of health, Labour market

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