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Job strain and the risk of stroke
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Job strain and the risk of stroke

an individual-participant data meta-analysis


BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.

METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.

RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.

CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

Fransson, E. I., Nyberg, S. T., Heikkilä, K., Alfredsson, L., Bjorner, J. B., Borritz, M., ... Kivimäki, M. (2015). Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke, 46(2), 557-9. DOI: 10.1161/STROKEAHA.114.008019
Author(s) Eleonor I Fransson
Solja T Nyberg
Katriina Heikkilä
Lars Alfredsson
Jakob B Bjorner
Marianne Borritz
Hermann Burr
Nico Dragano
Goedele A Geuskens
Marcel Goldberg
Mark Hamer
Wendela E Hooftman
Irene L Houtman
Matti Joensuu
Markus Jokela
Anders Knutsson
Markku Koskenvuo
Aki Koskinen
Meena Kumari
Constanze Leineweber
Thorsten Lunau
Ida E H Madsen
Linda L Magnusson Hanson
Martin L Nielsen
Maria Nordin
Tuula Oksanen
Jaana Pentti
Jan H Pejtersen, SFI
Reiner Rugulies
Paula Salo
Martin J Shipley
Andrew Steptoe
Sakari B Suominen
Töres Theorell
Salla Toppinen-Tanner
Jussi Vahtera
Marianna Virtanen
Ari Väänänen
Peter J M Westerholm
Hugo Westerlund
Marie Zins
Annie Britton
Eric J Brunner
Archana Singh-Manoux
G David Batty
Mika Kivimäki
Month of publish February 2015
Published in Stroke
Language English
Nr. of pages 3
Department Social Policy and Welfare
keywords Societal and employment-related aspects of health

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